Superior drug-free medical device coating

There is a significant issue with current treatments for peripheral artery disease (PAD) using stents.

BIOINVISIBLE is an anti-thrombogenic and anti-proliferative vascular coating, creating better outcomes for patients.

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Three Stents
Vi Solution A bioinvisible
Vi Solution B bioinvisible

Superior drug-free vascular device coating

Get the leading medical device coating technology that prevents the build-up of platelets, proteins and cells.

BIOINVISIBLE is a highly biocompatible coating that helps to make implantable materials less ‘visible’ to the body’s normal immune defences.

Currently, medical device complications result in implant failure rates of up to 30%, leaving many patients requiring additional medical intervention and surgery causing significant discomfort, morbidity or even death.

BIOINVISIBLE™ is the solution to reducing this failure rate.

Reducing platelet adhesion on vascular stents

Platelets are implicated in the development of stent thrombosis and in-stent restenosis. For a patient receiving a stent, the formation of fibrin clots on the surface of the stent can lead to larger and life-threatening blood clots that can block arteries, requiring emergency surgical intervention.

TekCyte’s BIOINVISIBLE coating creates a barrier on the surface of stents, which means the blood can flow normally over the stent surface. This reduces platelet adhesion and activation, greatly reducing the likelihood of a blood clot.

The unique coating has the potential to not only reduce complications from vascular devices, but it may also reduce the need for long-term anti-coagulant therapy for many patients requiring these devices.

Mouse models of restenosis show that BIOINVISIBLE coated stents significantly reduce the level of in-stent restenosis, compared with uncoated stents.

* Moore et al. (2022): Hyperbranched polyglycerol coated vascular stents – a non-pharmacological approach to reducing device-triggered thrombosis and restenosis – DOl is: 10.21203/rs.3.rs-1544665/v1

Uncoated vs coated metal stent

Bioinvisible Thrombosis Uncoated Bioinvisible Thrombosis Coated

Thrombosis

Bioinvisible Restenosis Uncoated Bioinvisible Restenosis Coated

Restenosis

BIOINVISIBLE™

The Process

We use a patented process where devices are coated with BIOINVISIBLE, a hydrophilic hyperbranched polyglycerol (HPG) polymer. This process allows the polymer to form directly from the surface of devices without the need for solvents.

Devices coated with BIOINVISIBLE repel platelets that can cause blood clots and potentially life-threatening complications for patients.

BIOINVISIBLE is easily applied to a wide range of metallic and polymer-based materials used in medical devices.

Vascular stents coated with BIOINVISIBLE repel platelets. This prevents blood clots which can lead to potential life-threatening complications for patients.

The BIOINVISIBLE process has patents granted in the US, Europe, China, Japan and Australia.

Stent Diagram

Successful NAMSA Tests

All studies showed no evidence of toxicity or sensitivity associated with exposure to BIOINVISIBLE.
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Evidence it works

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